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However, patients with homozygous or compound heterozygous mutations in the SECIS-binding protein SBP2, which is crucial for the synthesis of selenoproteins (111) have abnormal serum thyroid hormone levels: high (F)T4 and rT3, low T3, and somewhat elevated TSH levels

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The transplantation of cold-adapted microbiota results in modified intestinal gene expression that facilitates tissue remodeling and inhibits apoptosis, an effect that is attenuated by the co-transplantation Akkermansia muciniphila , during the transfer of cold microbiota 26

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