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These data link NF1 deficiency to fundamental shifts in muscle metabolism, and provide strong proof of principle that a dietary intervention can ameliorate muscle symptoms

In the DVT mouse model, endothelial activation and platelet function were stimulated by LPS but not by PAD4 deficiency, and PAD4 -/- mice formed NETs-free thrombi

As detailed in Sections Historical perspective and milestone events in protein folding and Causes and consequences of protein misfolding of this Review, complementary experimental and computational approaches have provided major insights into folding mechanics and proteostasis under normal physiology

Crystals were usually obtained in 2 to 5 days