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Ammonia Inability to generate urea from amino acids during end-stage liver disease, particularly during NASH and cirrhosis, can lead to hyperammonia
Compared to a known permeabilizing agent colistin, MAC13243 caused more severe OM leakage
The 2025 Randomized Controlled Trial: 30 mg Daily for 8 Weeks The most rigorous recent trial comes from a randomized, double-blind, placebo-controlled study published on medRxiv in October 2025
& Triebskorn, R
