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SIRT1 can bind and retain GAPDH in the cytosol, but SIRT5 actives GAPDH via demalonylation, thereby elevating glycolytic flux
JangEYuHKimEHwangJYooJChoiJet al
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CYP2E1 mRNA is one of the most expressed CYP450 isoforms in human left ventricular myocardium [27], and polymorphisms in CYP2E1 significantly interact with polycyclic aromatic hydrocarbons to influence congenital heart diseases (CHDs) [28]