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TABLE 3 Impact of melatonin on various antioxidant defense mechanisms

Experimental findings suggest that upregulated miRNAs such as miR-323/miR-326/miR-329, and miR-130a/miR-155/miR-210 could be related to downregulation of Nrf2 and subsequent increments in cell death leading to reduced mortality in glioblastoma patients [93]

Mechanisms linking environmental agents to the development of Autoimmune Diseases Oxidative stress-mediated disturbance of Nrf2, induction of NF-kB, PARP1, and NLRP3 can cause activation of both innate and adaptive immune systems, resulting in pro-inflammatory cytokines and production of autoantibodies, leading to tissue damage in Autoimmune disease

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