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/Investigators/ report also the metabolic fates of the synthetic metabolites: /compound/ 2 and /compound/ 3 were glucuronidated in rats, but only /compound/ 3 formed glutathione adducts in vivo and by enzymatic synthesis via a quinoneimine intermediate
Nevertheless, some studies have noted a heightened likelihood of edema and joint discomfort, which were temporary side effects that correlated with the dosage [30]
However, such a low dose of MeHg is clearly non-cytotoxic when MRP1 is fully active
