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Most pregnant individuals are not meeting the adequate intake (AI) for choline (450 mg/day)

PRDX3 and PRDX4 scavenge ROS within the mitochondria and ER, respectively, while PRDX5 and PRDX6 localize to multiple cellular compartments ( Additional detoxification systems include the thioredoxin (TRX1/2) pathway, which is particularly important for neutralizing ROS generated during disulfide bond formation in the ER, and superoxide dismutase 2 (SOD2), which catalyzes the conversion of superoxide into hydrogen peroxide (31, 32)

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In AD, the abnormal aggregation of amyloid-beta (A) protein contributes to increased oxidative stress, which is believed to play a central role in disease onset