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The evolution of GSH in aging fibroblasts showed a sudden increase in its concentration just before cell death, whereas GPx activity was already decreasing at the beginning of passages, and that of glutathione reductase was constant and reaching a very low level at the end of the cell culture, suggesting that the GSH system was probably involved in cell degeneration associated with aging [18]

It has 16 adjacent proteins in the PPI network, participates in the iron death metabolic pathway, and increases in expression with age, correlating with sex differences (Xu et al., 2024)

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The markers of lipid peroxidation include malonaldehyde (MDA), hydroxynonenal (HNE), and 8-isoprostaglandin F2 (Gopaul et al., 1995