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Drug Des Devel Ther Untargeted Metabolomics Investigating the Intracellular Metabolic Alterations of HaCaT Cells Treated with Isotretinoin

Owing to the critical physiologic role of l-carnitine in cellular fatty acid metabolism, there has been a belief that oral consumption of l-carnitine is beneficial in energy expenditure, when, in fact, there is equivocal evidence for enhancement in healthy individuals (4854)

It has been reported that muscle l-carnitine content increased following l-carnitine long-term oral administration [29,44,45] whereas failed to show elevated levels after short-term supplementation [43,46]

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