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Recent investigations have also indicated AKGs potential to support tissue repair and reduce toxin-induced cellular damage, making it a valuable addition to detoxification formulas (Iqbal et al., 2021)

In addition, a ligand-stimulated GSH transport which triggers the death of cells overexpressing MRP1, by collateral sensitivity (CS), has been described

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Ferroptosis, an iron-dependent regulated cell death (RCD) mechanism involving lipid peroxidation and glutathione (GSH) depletion, exhibits unique features distinct from other RCD forms (e.g., apoptosis, necrosis, and pyroptosis)