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Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis
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The role of environmental factors in ASD became evident with the observation that advanced paternal and maternal age is associated with an increased likelihood of having a child with ASD (Johnson et al., 2007), neocortical anomalies, macrocephaly in early life, and altered trophic signaling, all consistent with atypical neurodevelopmental trajectories (McCaffery and Deutsch, 2005)
