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A meta-analysis of four observational studies, following a total of 7,475 older individuals for 3 to 16 years, found a weak association between an elevation in vitamin B 12 of 50 pmol/L in blood and a reduction in fracture risk (114)

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Smooth muscle function recovery was also reviewed [3,4] (i.e., sphincter dysfunction (pupil [86], lower esophageal and pyloric sphincter [92,93,94,95,96,97,98,99], urethral sphincter [100,101,102], intestinal adaptation, and lesion recovery [103,104])

Ejemplo de planificacin de dosificacin de investigacin Principio: comenzar con una dosis baja y aumentarla gradualmente, dejando tiempo en cada nivel para evaluar la tolerancia