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For comparisons among three groups (e.g., serum cytokine measurements), pairwise MannWhitney U tests were performed, and p-values were adjusted using the Holm method to correct for multiple comparisons

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In one trial, the drospirenone COC group showed a greater percentage of changes for total, inflammatory, and noninflammatory lesion counts, as well as papule and closed comedone counts compared to the placebo

This heightened sensitivity predicts a higher likelihood of semaglutide-related nausea, and it also predicts a stronger response to pyridoxine anti-nausea effects