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As SUMOylation of TDP-43 plays a protective role in mice during aging, we assessed human brain samples and observed a positive correlation between global SUMOylation and age inferring an increased demand on SUMO-related pathways during aging

Therefore, the lack of changes in the activity of this enzyme even after very intense aerobic exercise lasting only a dozen or so minutes in our study is a normal reaction, which indirectly indicates the lack or slight reduction of carbohydrate resources in this period 63

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Inborn genetic errors in lipid metabolism such as membrane long-chain fatty acid transport, -oxidation, and the Krebs cycle could be fatal when implementing fasting or KD (121)