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These findings highlight the formulation-dependent bioavailability and functional effects of Mg, emphasizing the necessity of targeted supplementation strategies for neurological, muscular, and cardiovascular health

Understanding this mechanism matters because it explains why most GI side effects are dose-dependent, temporary, and manageable through titration strategies

UCP3, expressed primarily in the skeletal muscle, shares 59% homology to that of UCP1 and is regarded a plausible regulator of trans-membrane proton potential and hence efficiency of oxidative phosphorylation (242)

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