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Using Patch-seq, a negative correlation between the hepatocyte nuclear factor 1- (HNF1A) target gene FXYD2 (an inhibitory subunit of the Na + /K + -ATPase) and Na + influx was observed, suggesting a model whereby HNF1A facilitates membrane depolarisation and insulin secretion by upregulating sodium/potassium-transporting ATPase subunit (FXYD2)

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Remove your insulin needle from its packaging

An earlier study from the same group found that urban PM caused an increase in pro-inflammatory T helper 17 (TH17) cell response driven by IL-23 in a myeloid dendritic cell-memory CD4 + T cell co-culture system