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The first requires the participation of the nicotinamide riboside kinases (NRKs) (Chi and Sauve, 2013) in two of its isoforms (NRK1 and NRK2) (Bieganowski and Brenner, 2004) and the second requires the action of purine nucleoside phosphorylase (PNP) and nicotinamide phosphoribosyltransferase (NAMPT) (Burgos et al., 2013) (Figure 2)