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Additionally, at least five ancillary symptoms must be present, such as limb heaviness or generalized weakness, diminished concentration, or attention, decreased motivation or interest in usual activities, insomnia or hypersomnia, nonrestorative sleep, perceived need to struggle against inactivity, pronounced emotional response to fatigue, perceived short-term memory issues, or prolonged malaise following exertion (11)

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W., Goldbaum, L

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El sistema inmunolgico es en parte innato, pero an est inmaduro al nacer

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Thus, we propose that nLDs forming at the INM have two main developmental trajectories that lead to nuclear damage (Fig 16A)

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