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Acknowledgements This work was supported by the Swedish Brain Foundation (grant FO2023-0241), the Swedish Research Council (VR-NT grant 2022-04198, VR-TVAR 2021-03293), and the Science for Life Laboratory (all to P.E

The Caughey lab also characterized the N-terminal truncation (what we now call beta cleavage) of PrP Sc in cultured cells, and found that this proteolytic event (just like alpha cleavage) could be inhibited by either ammonium chloride (NH 4 Cl) or leupeptin [Caughey 1991]

Given the variable behavior of canine MCTs, there is a need to include new tests that provide additional information on biological behavior and clinical prognosis

This process usually involves physical therapy and occupational therapy, either via inpatient medical care at a hospital or at an outpatient center, depending on the severity of their injuries