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in contrast, chronic or constitutive Nrf2 overactivation due to somatic KEAP1/NFE2L2 mutations, epigenetic maladjustment, or persistent pharmacologic stimulation may be used to nourish tumor progression, chemoresistance, metabolic reprogramming and immune-evasive phenotypes in established cancers [15, 393, 394], [83]

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doi: 10.9754/journal.wmc.2013.004252 [DOI] [Google Scholar] 141

Exposure to high concentrations of Cl(2) results in acute lung injury that may either resolve spontaneously or progress to acute respiratory failure
