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This cytokine carries out the following activities: It attracts fibroblasts to the site and promotes their proliferation and transformation into myofibroblasts, promotes collagen production and deposition, acts as a recruiter for osteoblasts and promotes calcification and ossification of the PD plaque, promotes the production of TIMP-1, and promotes the production of MMP-2, which has elastase activity [21,22]

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