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In AD models, NOX2 upregulation following A stimulation promotes astrocyte reactivity, whereas NOX4 overexpression triggers oxidative stress-induced lipid peroxidation and mitochondrial dysfunction 94
Daines B, Wang H, Wang L, Li Y, Han Y, et al
These biomarkers are also used to track the efficacy of antioxidant therapies, with decreasing levels of MDA and 4-HNE indicating effective intervention [35]

This refers to the proportion of a nutrient that actually enters the bloodstream and becomes available for the body to use