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J.MoestrupS

There are 2 primary mechanisms: Ascorbic Acid (Ascorbate) uptake using sodium-dependent vitamin C transporter (SVCT) 1 or 2 Ascorbic Acid (Ascorbate) Recycling Ascorbic Acid (Ascorbate) transport using sodium-dependent vitamin C transporter (SVCT) 1 or 2 As shown below, SVCT 1 and SVCT 2 transport ascorbic acid or ascorbate into the cell against the concentration gradient (represented by the orange wedge in the figure below)

Two 5 5 Latin Squares balanced for first-order carry-over effects were employed for this crossover study (Additional file 1)

Several targeted covalent inhibitors are in late-stage clinical development and are showing encouraging efficacy