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Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial
Removing or inhibiting ROS formation should decrease tissue damage to an extent related to their antioxidant action in vivo
[DOI] [PMC free article] [PubMed] [Google Scholar] [27].Calzetta L, Matera MG, Rogliani P, Cazzola M

The evidence base is expanding steadily: a 2024 review in the International Journal of Molecular Sciences as well as a 2025 systematic review in the Journal of Cosmetic Dermatology both reported consistent improvements in fine lines, tone and elasticity, with minimal and short lived side-effects
