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ANG4043, a Novel Brain-Penetrant Peptide-MAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice

Immunohistochemical analysis of Iba-1 and GFAP showed that the number of activated astrocytes and microglia increased in both the striatum and substantia nigra after MPTP injection, and treatment with our formulation markedly alleviated MPTP-induced glial cell activation

reassessment should occur after 812 weeks with clinical guidance

These viral antigens possess analogous sequences and structures, favoring cross-reactivity of immune cells with autoantigens and the initiation or promotion of overproduction of autoantibodies (174)