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A link between the elevated cytokines levels in CNS and in peripheral blood has been observed in postmortem studies of BD patients [138]
They also have chronic pain in muscles, ligaments, and joints
Young SZ, Taylor MM, Bordey A
In the microenvironment of solid tumors, hypoxia has been shown to stimulate autophagy in tumor-associated blood vessels which in turn can alter metabolic pathways and surface markers of endothelial cells (Verhoeven et al., 2021)
