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Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke

Trabelsi et al., 2012), but there was no known commercially available affinity chromatography ligand for CVA21

Recent preclinical mouse models have shown that immune-targeting the xCT antigen can enhance the activity of a viral vectors-based vaccine against HER2, and reduces the growth of HER2+ breast cancer, frequency of CSCs and metastatic events (85)

In addition, included were, i.e., 4-week intravenous toxicity in rats followed by 4 weeks of recovery, 4-week intravenous toxicity in dogs, sub-acute (14 days) intracolonic toxicity study in rats and Beagle dogs, a repeated dose (28 days) dermal toxicity study in Wistar rats, chromosome aberrations in human lymphocytes cultured in vitro, an Ames test, a micronucleus test, female fertility and early embryonal development after intravenous administration to rats, embryofetal development after intravenous administration to rats (including toxicokinetics in pregnant animals and placental transfer), embryofetal development after intravenous administration in New Zealand White rabbits, cardiovascular and respiratory systems in anesthetized dog, a sensitization study in guinea pigs (Maximization test), and an acute eye irritation/corrosion study in albino rabbits