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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

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In leaner areas like the thigh, a 45-degree angle may be more appropriate

That makes supplier transparency, third-party HPLC purity confirmation, and lot-specific certificates non-negotiable for any research-context sourcing
