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Supplements With Clinical Evidence for Sperm Health The supplement landscape is crowded, but several nutrients have robust clinical evidence supporting their role in male fertility: CoQ10 (Coenzyme Q10): A landmark 2012 randomised controlled trial published in the Journal of Urology found that CoQ10 supplementation (300 mg/day for 26 weeks) significantly improved sperm density, motility, and morphology in men with idiopathic oligoasthenoteratospermia