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Lyon, F: IARC (2018)

Clinical differential diagnosis of this entity includes malignant melanoma, pigmented Basal Cell Carcinoma (BCC), and hemangioma.3 Histopathological differential diagnosis includes tumors with matrical differentiation, such as pilomatricoma with melanocytic hyperplasia, malignant pilomatricoma, matricoma, BCC with matrical differentiation3 and, most challengingly, malignant melanocytic matricoma, an extremely rare tumor with only 8 reported cases.5 Proposed criteria for differentiating benign and malignant melanocytic matricoma remain controversial2,5

Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate

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