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67,68,69 Some studies considered astrocytes can arise barrier behaviors in cerebral, other endothelial cells, and related epithelial, while other studies thought the BBB goes first before the appearance of astrocytes

PMID: 92 NychasEMarfil-SnchezAChenXMirhakkakMLiHJiaWet al

Mol Pharmacol 74(4):11011108 Murakoshi H, Wang H, Yasuda R (2011) Local, persistent activation of Rho GTPases during plasticity of single dendritic spines