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Given its ample range of functions in the nervous system, it is not surprising to find significant alterations in glutathione levels and/or glutathione-related enzymes during brain aging and in several neurological conditions including Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), schizophrenia, and chronic fatigue syndrome (CFS)

A cohort study also reported that high-altitude exposure leads to intestinal mucosal barrier damage and the release of pro-inflammatory cytokines, such as TNF- and IL-1 (Zhang Y

doi: 10.3389/fphar.2025.1669805 Received 20 July 2025 Accepted 21 August 2025 Published 18 September 2025 Volume 16 - 2025 Edited by Juei-Tang Cheng, Chang Jung Christian University, Taiwan Reviewed by Phiwayinkosi V