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Under hypoxic conditions, BCSC stemness is maintained through the Notch, Wnt and Hh signaling pathways, which leads to the emergence of drug resistance [233,234]
"Interphalangeal joint anatomy"
While mouse strains and their hybrids differ in susceptibility to hypoxia, C57BL/6 appear to be an intermediate type, neither particularly sensitive nor tolerant to hypoxia (Sheldon et al., 1998)
