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The paracellular translocation of macromolecules up to 125 is carried out by a low-capacity leak pathway regulated by zonula occludens (ZO), occludins, and tricellulins (Odenwald and Turner 2017

This framework prevents the peptide from collapsing, protects it from thermal shock, and ensures rapid dissolution during mixing.

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Again, similar histological effects were observed in the shorter time frames of 2 and 4 weeks after puncture surgery
