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The diploid gene 134.5 located within the inverted terminal repeats flanking the long unique sequence of HSV-1 DNA is classified as a gamma-late or leaky late gene

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Although initially suggested to act via recruiting HDAC3, Xist-mediated silencing is abolished by SHARP deletion, but only attenuated upon HDAC3 deletion 48,49 , suggesting that additional mechanisms are involved in SHARP-dependent repression of the X-chromosome

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