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doi: 10.1016/j.brs.2023.05.014 69 KongL.LiX

Following sequestration, IL-6 can bind to other cells via type I cytokine receptor [100], activating various transcription factors such as the JAK/STAT pathway, enhancing pro-inflammatory responses, e.g., via increased APP production

doi: 10.3389/fimmu.2022.850416 89 BorkumJM

Only 12% of internalized LNP-loaded siRNAs were released into the cytoplasm, and this only occurred within a limited time frame after internalization
