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674 The 9,10- and 12,13-DiHOMEs also induced renal proximal tubule cell death associated with mitochondrial dysfunction, while the corresponding epoxide did not induce cell death at concentrations up to 1 mM

Among the risk factors, we can find age, family history, certain genetic mutations, diet, and lifestyle factors [185]

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In PD, disruption of proteostasis is strongly linked to dysfunction in both the UPS and ALP