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The two directions of cause and effect are easy to mix up, and untangling them is the first step to understanding this topic correctly
This inverted-U dose-response pattern is important: more is not better with GSB-106
[DOI] [PubMed] [Google Scholar] 69.Kandola A, Ashdown-Franks G, Hendrikse J, Sabiston CM, Stubbs B
Moreover, NK cells transfected with small interfering RNA (siRNA) against PRF1 showed dramatic decreases in PRF1 expression, coupled with downregulated NK cell cytotoxicity (data not shown), suggesting that perforin is an essential factor for determining NK cell killing capacity
