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Description
Long-term dysbiosis leads to overstimulation of neuroimmune system and the hypothalamicpituitaryadrenocortical axis, along with neurotransmitter imbalance

As cell size has been linked to changes in metabolism [20, 21], we hypothesised that metabolic disturbances contribute to the increase in spontaneous cell death in ADA2 deficiency
doi: 10.1200/JOP.2011.000486 273

James E
