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In a randomized clinical trial, supplementation reduced inflammatory markers and improved certain metabolic parameters
Chatelain PG, Sanchez P, Saez JM: Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice
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Additionally, it is important to correct cobalamin deficiency before starting folic acid treatment, or provide cyanocobalamin together with folic acid
