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Currently, certain drugs that alleviate oxidative stress and inflammation by eliminating ROS, such as thioproline and N-acetylcysteine, have been applied in IBD clinical treatments ( 4 The regulatory role of gut microbiota dysbiosis in the pathogenesis of IBD Clinical data indicate a significant positive correlation between gut microbiota dysbiosis and the onset and progression of IBD, manifested specifically as reduced -diversity, depletion of commensal probiotic bacteria, and abnormal proliferation of pro-inflammatory pathogens ( 4.1 Immune imbalance Immune imbalance is the key amplifier that converts dysbiosis and epithelial stress into sustained inflammatory signaling, which subsequently perturbs iron regulation and favors ferroptosis-prone states

CJEM 12: 449452, 2010 [DOI] [PubMed] [Google Scholar] 24.Lawrence DT, Bechtel LK, Charlton NP, Holstege CP: 5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose