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Indirect effects of renal function In addition to myocardial injury, TMAO indirectly affects the progression of HF by influencing renal function ( Based on the role of TMAO in the progression of HF, regulating TMAO levels is a new and attractive therapeutic target for HF treatment ( TMAO and hypertension By 2025, the total number of patients with hypertension is expected to reach 1.56 billion and the average age of patients tends to be younger ( Figure 5 )

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