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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide

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227,228 In addition, PPAR agonists can also inhibit pulmonary fibrosis, which is expected to be a drug to prevent small airway fibrosis in COPD

The 15 mg/mL concentration (2.0 mL water) is the most concentrated practical option for this vial size