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Additionally, key binding residues such as His251 and Tyr235 align with known functional sites critical for TPH activity, as demonstrated in structural studies of the enzyme [89]

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Pharmacology of OR has been described with the message/address model: the ligand is composed of two parts, one carrying the activity (agonist or antagonist) at the different subtypes of OR, the message and one part, the address, conveying selectivity toward a given OR (Portoghese et al., 1990)