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MiR-16 overexpression reduced cell proliferation in vitro and tumor growth in mice by targeting directly the IGF1R with subsequent inhibition of the Raf1- Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2)-ERK1/2 pathway (77)

Dynamic light scattering (DLS) instrument (Santa Barbara, CA, USA) that was utilized to ascertain the average particle size distribution in nm and average zeta potential in mV, in conditions 23 C, with the incident light being the 632.8 nm line of a HeNe laser at an angle of 13.9)

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