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A true acne scar involves structural changes, including indentations (atrophic scars like icepick, boxcar, and rolling scars) or raised tissue (hypertrophic scars)
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The imaging was performed using the High content imager CX7 (Thermo Fisher) with a HCS Studio 4.0 software, and phenotyping and quantifications were performed using ImageJ v1.53 or CellProfiler v3 softwares
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