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doi:10.1155/2021/9930059

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Age-related microvascular degeneration, characterized by endothelial dysfunction, pathological extracellular matrix remodeling, and loss of vascular elasticity, further compromises microvascular integrity, heightening susceptibility to CMHs that eventually leads to neurological symptoms [17, 23, 27,28,29,30,31]

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The term implies that there is a causal connection, the cerebellar defects being primary and the subcerebellar defects being secondary, but such an implication is less likely to be valid for the cerebellar hypoplasias than for the cerebellar atrophies

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