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There is a significant difference for the secondary outcome, mental health status, by using assessment score, BDI score in one group, which favored placebo (MD 2.50, 95% CI [2.352.65]

10.3390/ijms17020189 Int

The good news is that research suggests these two supplements can indeed complement each other

Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems
