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Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria

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The mRNA transcripts regulating spermatogenesis (e.g., ODF2 and SPATA18 ), nuclear genome structure (e.g., PRM1 , OAZ3 , HSPB9 , and NDUFS4 ), mitochondrial function ( e.g., COX1ATP8 ), and fertilization (e.g., HSPA1L and PRSS37 ) were observed to be associated with compaction of sperm chromatin, energy metabolism, oxidative stress, apoptosis, and early embryo development (Sendler et al., 2013

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