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Description
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Less often, they are found on the apical membrane being constantly exposed to commensal microorganisms and microbial products that are ligands for specific TLRs (Yu and Gao, 2015)
It catalyzes the conversion of L-cysteine, L-glutamate, and ATP into -glutamylcysteine
Early events include mutation in tumor suppressive genes such as p53 (up to 64% of tumors) and p21 (up to 55% of tumors)
